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Intraduodenal and intrajejunal administration of the herbal medicine, dai-kenchu-tou, stimulates small intestinal motility via cholinergic receptors in conscious dogs.

Abstract
The aim of the present study was to study the effect and mechanism of action of intraduodenal and intrajejunal dai-kenchu-to, an herbal medicine clinically effective for uncomplicated postoperative adhesive intestinal obstruction, on upper gastrointestinal motility. Five mongrel dogs were equipped with four strain-gauge force transducers on the antrum, duodenum, and proximal and distal jejunum to measure contractile activity. Dai-kenchu-to (0.5, 1.5, and 3.0 g) was administered into the duodenal or proximal jejunal lumen. The effect of atropine, hexamethonium, phentolamine, propranolol, and ondansetron on intraduodenal and intrajejunal dai-kenchu-to-induced contractions was studied. Plasma motilin was measured by specific radioimmunoassay. Intraduodenal and intrajejunal dai-kenchu-to induced phasic contractions in the duodenum and proximal jejunum, respectively, and those contractions migrated distally. Phasic contractions induced by intraduodenal and intrajejunal dai-kenchu-to were inhibited by atropine and hexamethonium at all sites. Plasma motilin was not affected by dai-kenchu-to. Intraduodenal and intrajejunal dai-kenchu-to stimulates upper gastrointestinal motility at and distal to the administration sites through cholinergic receptors.
AuthorsX L Jin, C Shibata, H Naito, T Ueno, Y Funayama, K Fukushima, S Matsuno, I Sasaki
JournalDigestive diseases and sciences (Dig Dis Sci) Vol. 46 Issue 6 Pg. 1171-6 (Jun 2001) ISSN: 0163-2116 [Print] United States
PMID11414290 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Pharmaceutical Preparations
  • Plant Extracts
  • Receptors, Cholinergic
  • dai-kenchu-to
  • Motilin
Topics
  • Animals
  • Consciousness
  • Dogs
  • Duodenum
  • Female
  • Gastrointestinal Motility (drug effects)
  • Intestine, Small (drug effects, physiology)
  • Jejunum
  • Male
  • Motilin (blood)
  • Panax
  • Pharmaceutical Preparations
  • Plant Extracts (administration & dosage)
  • Plants, Medicinal
  • Receptors, Cholinergic (physiology)
  • Zanthoxylum
  • Zingiberaceae

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