Abstract |
The aim of the present study was to study the effect and mechanism of action of intraduodenal and intrajejunal dai-kenchu-to, an herbal medicine clinically effective for uncomplicated postoperative adhesive intestinal obstruction, on upper gastrointestinal motility. Five mongrel dogs were equipped with four strain-gauge force transducers on the antrum, duodenum, and proximal and distal jejunum to measure contractile activity. Dai-kenchu-to (0.5, 1.5, and 3.0 g) was administered into the duodenal or proximal jejunal lumen. The effect of atropine, hexamethonium, phentolamine, propranolol, and ondansetron on intraduodenal and intrajejunal dai-kenchu-to-induced contractions was studied. Plasma motilin was measured by specific radioimmunoassay. Intraduodenal and intrajejunal dai-kenchu-to induced phasic contractions in the duodenum and proximal jejunum, respectively, and those contractions migrated distally. Phasic contractions induced by intraduodenal and intrajejunal dai-kenchu-to were inhibited by atropine and hexamethonium at all sites. Plasma motilin was not affected by dai-kenchu-to. Intraduodenal and intrajejunal dai-kenchu-to stimulates upper gastrointestinal motility at and distal to the administration sites through cholinergic receptors.
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Authors | X L Jin, C Shibata, H Naito, T Ueno, Y Funayama, K Fukushima, S Matsuno, I Sasaki |
Journal | Digestive diseases and sciences
(Dig Dis Sci)
Vol. 46
Issue 6
Pg. 1171-6
(Jun 2001)
ISSN: 0163-2116 [Print] United States |
PMID | 11414290
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Pharmaceutical Preparations
- Plant Extracts
- Receptors, Cholinergic
- dai-kenchu-to
- Motilin
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Topics |
- Animals
- Consciousness
- Dogs
- Duodenum
- Female
- Gastrointestinal Motility
(drug effects)
- Intestine, Small
(drug effects, physiology)
- Jejunum
- Male
- Motilin
(blood)
- Panax
- Pharmaceutical Preparations
- Plant Extracts
(administration & dosage)
- Plants, Medicinal
- Receptors, Cholinergic
(physiology)
- Zanthoxylum
- Zingiberaceae
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