Expression of nm23-H1 in hydatidiform mole and its relationship with the development of postmolar disease.

Abstract

The aim of the present study was to investigate the expression of nm23-H1 in human placenta, hydatidiform mole and choriocarcinoma cells. Nm23-H1 protein was localized in the cytotrophoblast, but not in the syncytiotrophoblast. In the hydatidiform mole cases with subsequent spontaneous remission, nm23-H1 mRNA levels were significantly lower than those in first-trimester placentas. However, its levels were elevated in the hydatidiform mole cases that progressed to persistent gestational trophoblastic disease and were comparable to those of first-trimester placentas, and they were further elevated in choriocarcinoma cells. The present data suggest an association of nm23-H1 for the proliferation activity of trophoblast, and its increased expression may influence the development of persistent trophoblastic disease.

• Authors: K Iwase, T Okamoto, R Nui, S Mizutani
• Journal: Gynecologic and obstetric investigation (Gynecol Obstet Invest) Vol. 51 Issue 4 Pg. 228-32 ( 2001) ISSN: 0378-7346 [Print] Switzerland
• PMID: 11408732 (Publication Type: Journal Article)
• Copyright: Copyright 2001 S. Karger AG, Basel

Chemical References

• NM23 Nucleoside Diphosphate Kinases
• RNA, Messenger
• Transcription Factors
• NME1 protein, human
• Nucleoside-Diphosphate Kinase
• Monomeric GTP-Binding Proteins

Topics

• Blotting, Northern
• Choriocarcinoma (chemistry)
• Female
• Gestational Age
• Humans
• Hydatidiform Mole (chemistry, complications)
• Immunohistochemistry
• Monomeric GTP-Binding Proteins (analysis, genetics)
• NM23 Nucleoside Diphosphate Kinases
• Nucleoside-Diphosphate Kinase
• Placenta (chemistry)
• Pregnancy
• RNA, Messenger (analysis)
• Transcription Factors (analysis, genetics)
• Trophoblastic Neoplasms (chemistry, etiology)
• Trophoblasts (chemistry)
• Tumor Cells, Cultured
• Uterine Neoplasms (chemistry, complications)