Abstract |
The aim of the present study was to investigate the expression of nm23-H1 in human placenta, hydatidiform mole and choriocarcinoma cells. Nm23-H1 protein was localized in the cytotrophoblast, but not in the syncytiotrophoblast. In the hydatidiform mole cases with subsequent spontaneous remission, nm23-H1 mRNA levels were significantly lower than those in first-trimester placentas. However, its levels were elevated in the hydatidiform mole cases that progressed to persistent gestational trophoblastic disease and were comparable to those of first-trimester placentas, and they were further elevated in choriocarcinoma cells. The present data suggest an association of nm23-H1 for the proliferation activity of trophoblast, and its increased expression may influence the development of persistent trophoblastic disease.
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Authors | K Iwase, T Okamoto, R Nui, S Mizutani |
Journal | Gynecologic and obstetric investigation
(Gynecol Obstet Invest)
Vol. 51
Issue 4
Pg. 228-32
( 2001)
ISSN: 0378-7346 [Print] Switzerland |
PMID | 11408732
(Publication Type: Journal Article)
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Copyright | Copyright 2001 S. Karger AG, Basel |
Chemical References |
- NM23 Nucleoside Diphosphate Kinases
- RNA, Messenger
- Transcription Factors
- NME1 protein, human
- Nucleoside-Diphosphate Kinase
- Monomeric GTP-Binding Proteins
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Topics |
- Blotting, Northern
- Choriocarcinoma
(chemistry)
- Female
- Gestational Age
- Humans
- Hydatidiform Mole
(chemistry, complications)
- Immunohistochemistry
- Monomeric GTP-Binding Proteins
(analysis, genetics)
- NM23 Nucleoside Diphosphate Kinases
- Nucleoside-Diphosphate Kinase
- Placenta
(chemistry)
- Pregnancy
- RNA, Messenger
(analysis)
- Transcription Factors
(analysis, genetics)
- Trophoblastic Neoplasms
(chemistry, etiology)
- Trophoblasts
(chemistry)
- Tumor Cells, Cultured
- Uterine Neoplasms
(chemistry, complications)
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