Domino hepatic transplantation using the liver from a patient with primary hyperoxaluria.

Abstract

BACKGROUND:

We report a case of domino liver transplantation using the liver harvested from a patient who underwent a combined liver and kidney transplantation for primary hyperoxaluria (PH).

METHOD:

A cadaveric liver transplantation was performed in a 19-year-old man with PH. In a second step, the PH liver harvested from the first patient was transplanted in a 69-year-old man with hepatitis C-related cirrhosis, not a candidate for a classic liver graft owing to multifocal hepatocellular carcinoma.

RESULTS:

At 8 months after transplantation, the domino recipient has normal hepatic function and no signs of tumoral recurrence, but he progressively developed hyperoxalemia, hyperoxaluria, and renal insufficiency.

CONCLUSION:

Regarding the favorable postoperative clinical evolution, domino liver transplantations using livers from PH patients may represent a new opportunity for marginal candidates for liver transplantation. However, the progressive renal insufficiency expected in such domino recipients should limit this procedure to selected cases.

• Authors: V Donckier, I El Nakadi, J Closset, B Ickx, H Louis, O Le Moine, N Bourgeois, M Adler, M Gelin
• Journal: Transplantation (Transplantation) Vol. 71 Issue 9 Pg. 1346-8 (May 15 2001) ISSN: 0041-1337 [Print] United States
• PMID: 11397976 (Publication Type: Case Reports, Journal Article)

Topics

• Adult
• Aged
• Cadaver
• Humans
• Hyperoxaluria (etiology, surgery)
• Liver
• Liver Transplantation (adverse effects, methods)
• Male
• Tissue and Organ Harvesting (methods)
• Tissue and Organ Procurement