The effects of cidofovir on progressive multifocal leukoencephalopathy: an MRI case study.

Abstract

MRI was used to study the effects of introducing cidofovir (HPMPC, Vistide) to the antiretroviral therapy of a 33-year-old white man diagnosed as having progressive multifocal leukoencephalopathy (PML) secondary to AIDS. In response to combined cidofovir and antiretroviral therapy he showed significant clinical improvement. MRI showed a decrease in extent of existing lesions, without new ones. Blood chemistry information obtained indicated some involvement of immunologic mechanisms: the CD4:8 ratio showed improvement from an average of 0.08 before treatment to 0.13 during therapy.

• Authors: R L Cardenas, K H Cheng, K Sack
• Journal: Neuroradiology (Neuroradiology) Vol. 43 Issue 5 Pg. 379-82 (May 2001) ISSN: 0028-3940 [Print] Germany
• PMID: 11396742 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-HIV Agents
• Organophosphonates
• Organophosphorus Compounds
• Cytosine
• Cidofovir

Topics

• Adult
• Anti-HIV Agents (therapeutic use)
• Cidofovir
• Cytosine (analogs & derivatives, therapeutic use)
• Humans
• Leukoencephalopathy, Progressive Multifocal (drug therapy, pathology)
• Magnetic Resonance Imaging
• Male
• Organophosphonates
• Organophosphorus Compounds (therapeutic use)