Abstract |
In a prospective, randomized, open study, the therapeutic efficacy of a long-term prophylaxis with standard heparin (SH) was compared with that of low-molecular-weight heparin ( LMWH) Dalteparin in 166 patients who had spinal fractures with spinal cord injury. 86 patients were treated with SH 2 x 7500 U s.c. and 80 patients were treated with LMWH 1 x 5000 anti-Xa U s.c. once daily. The screening was implemented by daily bedside-examination. In case of clinical thromboembolism-symptoms patients had confirmatory venography or lung scans. In the SH-group 12 (14.0%) patients had deep vein thrombosis and in the LMWH-group 6 (7.5%). Pulmonary embolism was detected two times in the SH-group (2.33%) and only one time in the LMWH-group (1.25%). A significant difference could not be shown, but is descriptive evident.
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Authors | U Lohmann, E Gläser, B E Braun, U Bötel |
Journal | Zentralblatt fur Chirurgie
(Zentralbl Chir)
Vol. 126
Issue 5
Pg. 385-90
(May 2001)
ISSN: 0044-409X [Print] Germany |
Vernacular Title | Thromboembolieprophylaxe bei Wirbelsäulenfrakturen mit Rückenmarkverletzungen. Standard-Heparin versus niedermolekulares Heparin bei frischen Querschnittsyndromen. |
PMID | 11396248
(Publication Type: Clinical Trial, Comparative Study, English Abstract, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Heparin, Low-Molecular-Weight
- Heparin
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Topics |
- Acute Disease
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Dose-Response Relationship, Drug
- Drug Administration Schedule
- Female
- Heparin
(administration & dosage, adverse effects)
- Heparin, Low-Molecular-Weight
(administration & dosage)
- Humans
- Long-Term Care
- Male
- Middle Aged
- Paraplegia
(complications, drug therapy)
- Prospective Studies
- Spinal Cord Injuries
(complications, drug therapy)
- Spinal Fractures
(complications, drug therapy)
- Thromboembolism
(etiology, prevention & control)
- Treatment Outcome
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