Abstract |
It is known that thymidine phosphorylase (dThdPase) is increased in various types of malignant tumors and is induced by cytokines. In this study, we have investigated the effects of OK-432, which induces multiple cytokines, on dTHdPase expression and angiogenesis in human gastric carcinomas. We examined 25 patients who underwent gastrectomy for gastric carcinoma. OK-432 was directly injected in tumors in 16 (OK group) of 25 patients via endoscopy before operation and the other 9 patients were not treated (control group). The dThdPase activity in carcinoma tissues of the OK group was significantly higher than that of the control group (P < 0.05). The amounts of IL-1 alpha, IFN-alpha, and IFN-gamma in carcinomas in the OK group were significantly higher than in the controls (P < 0.05), and these were significantly correlated with the dThdPase activity. Intratumoral OK-432 administration enhances the expression of dThdPase in gastric carcinoma cells by inducing various cytokines.
|
Authors | K Ogawa, S Konno, Y Takebayashi, M Murayama, T Shimakawa, T Katsube, Y Naritaka, T Kajiwara, M Aiba, S Akiyama |
Journal | Anticancer research
(Anticancer Res)
2001 Mar-Apr
Vol. 21
Issue 2B
Pg. 1257-62
ISSN: 0250-7005 [Print] Greece |
PMID | 11396196
(Publication Type: Journal Article)
|
Chemical References |
- Antineoplastic Agents
- Interferon-alpha
- Interleukin-1
- Picibanil
- Interferon-gamma
- Thymidine Phosphorylase
|
Topics |
- Antineoplastic Agents
(administration & dosage, therapeutic use)
- Capillaries
- Female
- Humans
- Interferon-alpha
(biosynthesis)
- Interferon-gamma
(biosynthesis)
- Interleukin-1
(biosynthesis)
- Male
- Middle Aged
- Picibanil
(administration & dosage, therapeutic use)
- Stomach Neoplasms
(drug therapy, enzymology, pathology)
- Thymidine Phosphorylase
(biosynthesis)
|