Critical age of botulinum toxin treatment in essential infantile esotropia.

Abstract

PURPOSE:

To assess the results of botulinum toxin treatment in 60 consecutive children with essential infantile esotropia.

METHODS:

Bilateral simultaneous injection of botulinum toxin into the medial rectus muscle was performed in 60 patients under direct visualization with an "open sky" technique. Fluothane/sevoflurane insufflation anesthesia was used. Each patient underwent a single bilateral botulinum toxin injection. Patient age at the time of injection ranged from 5-8 months.

RESULTS:

Mean patient age at the time of treatment for the 88% of patients who gained a good alignment (within +10 prism diopters [delta] of residual esotropia) was 6.5 months, while mean patient age at time of injection for the 12% of patients who were undercorrected or the deviation relapsed was 7.8 months. Follow-up averaged 5.2 years (range: 2-9 years, SD 2). No variation of the angle of strabismus was observed after 6 months from injection. In some patients with hyperopic refraction, plus lens corrections were prescribed during follow-up to stabilize the alignment.

CONCLUSION:

Botulinum toxin can be effective in essential infantile esotropia when children are treated by age 7 months.

• Authors: E C Campos, C Schiavi, C Bellusci
• Journal: Journal of pediatric ophthalmology and strabismus (J Pediatr Ophthalmol Strabismus) 2000 Nov-Dec Vol. 37 Issue 6 Pg. 328-32; quiz 354-5 ISSN: 0191-3913 [Print] United States
• PMID: 11392405 (Publication Type: Journal Article)

Chemical References

• Anti-Dyskinesia Agents
• Botulinum Toxins

Topics

• Age Factors
• Anti-Dyskinesia Agents (therapeutic use)
• Botulinum Toxins (therapeutic use)
• Esotropia (drug therapy)
• Female
• Humans
• Infant
• Injections
• Male
• Oculomotor Muscles (drug effects)
• Treatment Outcome
• Vision, Binocular