[Indications of fetal chromosome abnormalities in 1st trimester ultrasound].

Abstract

The measurement of the nuchal translucency and the evaluation of other sonographic signs in the first trimester scan allow a detection rate of 70-80% of aneuploid pregnancies, significantly more than with consideration of the maternal age alone (30%). The sonographic signs include the early growth retardation, deviations of the fetal heart rate, exomphalos, megacystis, holoprosencephaly and enlargement of the cisterna magna. Maternal serum biochemistry alone (PAPP-A and beta-hCG or alpha-fetoprotein, estriol and beta-hCG) detects about 65% of aneuploid pregnancies. The best individual risk estimation is based on maternal age, measurement of the nuchal translucency and the maternal biochemistry.

• Authors: K J Biedermann
• Journal: Praxis (Praxis (Bern 1994)) Vol. 90 Issue 18 Pg. 779-83 (May 03 2001) ISSN: 1661-8157 [Print] Switzerland
• Vernacular Title: Hinweise auf fetale Chromosomenstörungen Ersttrimester-Ultraschall.
• PMID: 11392281 (Publication Type: Journal Article)

Topics

• Adult
• Aneuploidy
• Chromosome Aberrations (diagnostic imaging)
• Chromosome Disorders
• Female
• Humans
• Infant, Newborn
• Maternal Age
• Middle Aged
• Pregnancy
• Pregnancy Trimester, First
• Risk Factors
• Ultrasonography, Prenatal