The chemistry and biological effects of malondialdehyde-acetaldehyde adducts.

Abstract

This article represents the proceedings of a workshop at the 2000 ISBRA Meeting in Yokohama, Japan. The chairs were Geoffrey M. Thiele and Simon Worrall. The presentations were (1) The chemistry of malondialdehyde-acetaldehyde (MAA) adducts, by Dean J. Tuma; (2) The formation and clearance of MAA adducts in ethanol-fed rats, by Simon Worrall; (3) Immune responses to MAA adducts may play a role in the development of alcoholic liver disease, by Lynell W. Klassen; (4) Unique biological responses to MAA-modified proteins that may play a role in the development and/or progression of alcoholic liver disease, by Geoffrey M. Thiele; (5) MAA-adducted bovine serum albumin activates protein kinase C and stimulates interleukin-8 release in bovine bronchial epithelial cells, by Todd A. Wyatt; and (6) An enzyme immune assay for serum antiacetaldehyde adduct antibody using low-density lipoprotein-adduct and its significance in alcoholic liver injury and ALDH2 heterozygotes, by Naruhiko Nagata.

• Authors: G M Thiele, S Worrall, D J Tuma, L W Klassen, T A Wyatt, N Nagata
• Journal: Alcoholism, clinical and experimental research (Alcohol Clin Exp Res) Vol. 25 Issue 5 Suppl ISBRA Pg. 218S-224S (May 2001) ISSN: 0145-6008 [Print] England
• PMID: 11391074 (Publication Type: Journal Article, Review)

Chemical References

• Central Nervous System Depressants
• DNA Adducts
• Ethanol
• Malondialdehyde
• ALDH2 protein, human
• Aldehyde Dehydrogenase
• Aldehyde Dehydrogenase, Mitochondrial
• Acetaldehyde

Topics

• Acetaldehyde (metabolism)
• Aldehyde Dehydrogenase (drug effects, metabolism)
• Aldehyde Dehydrogenase, Mitochondrial
• Animals
• Central Nervous System Depressants (pharmacology)
• DNA Adducts (drug effects, metabolism)
• Ethanol (pharmacology)
• Humans
• Liver Diseases, Alcoholic (metabolism)
• Malondialdehyde (metabolism)
• Mice