Abstract | PURPOSE: To evaluate the efficacy of mitomycin C in reducing reformation of adhesions following surgery for restrictive strabismus. METHODS: Sixteen patients with restrictive strabismus resulting from trauma, retinal detachment surgery, and multiple squint surgeries were randomized to either a mitomycin group (8 patients) or a control group (8 patients). Mitomycin C (0.2 mg/mL) was applied intraoperatively for 5 minutes after release of adhesions. Range of passive ductions was scored for comparison. Postoperative follow-up ranged from 3-18 months. RESULTS: Compared to controls, the mitomycin C group had better range of passive ductions. There were no complications related to the cornea, intraocular pressure, uveitis, or muscle disinsertion in the mitomycin C group. CONCLUSION: Intraoperative application of mitomycin C (0.2 mg/mL for 5 minutes) is a safe and effective adjunct to surgery in the treatment of restrictive strabismus.
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Authors | A Mahindrakar, R Tandon, V Menon, P Sharma, S Khokhar |
Journal | Journal of pediatric ophthalmology and strabismus
(J Pediatr Ophthalmol Strabismus)
2001 May-Jun
Vol. 38
Issue 3
Pg. 131-5; quiz 172-3
ISSN: 0191-3913 [Print] United States |
PMID | 11386644
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Antibiotics, Antineoplastic
- Mitomycin
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Topics |
- Adolescent
- Adult
- Antibiotics, Antineoplastic
(therapeutic use)
- Chemotherapy, Adjuvant
- Child
- Double-Blind Method
- Female
- Fibroblasts
(drug effects)
- Follow-Up Studies
- Humans
- Male
- Mitomycin
(therapeutic use)
- Postoperative Complications
(drug therapy)
- Prospective Studies
- Recurrence
- Strabismus
(surgery)
- Tissue Adhesions
(prevention & control)
- Treatment Outcome
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