Abstract |
Knowledge of selective muscle-involvement is useful to the clinician. Therefore we investigated in sarcoglycanopathy and dysferlinopathy: (i) the correlation between clinical scale, MRC scale and CT findings and (ii) the muscles involved. Patients with a definite diagnosis of dysferlinopathy and sarcoglycanopathy were tested for their clinical functions and muscle strength and assigned a functional grade. Nineteen muscles were evaluated by CT. In dysferlinopathy, distal lower-limb muscles are involved, while in sarcoglycanopathy proximal muscles are more affected. In both groups, muscles with MRC < 3 often had severe abnormalities on CT imaging, while muscles with MRC > 4 could be either normal or abnormal. Dysferlinopathy and sarcoglycanopathy have different and selective muscle involvement. This may affect certain types of functional activity. There is a possible relationship between CT findings and MRC grade in muscles with a low (< 3) MRC grade. Abnormality on CT scan may precede the clinical symptoms.
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Authors | M Vlak, E van der Kooi, C Angelini |
Journal | Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
(Neurol Sci)
Vol. 21
Issue 5 Suppl
Pg. S975-7
( 2000)
ISSN: 1590-1874 [Print] Italy |
PMID | 11382199
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Topics |
- Adult
- Diagnosis, Differential
- Disability Evaluation
- Female
- Humans
- Male
- Muscle Weakness
(diagnostic imaging, pathology, physiopathology)
- Muscle, Skeletal
(diagnostic imaging, pathology, physiopathology)
- Muscular Dystrophies
(diagnostic imaging, pathology, physiopathology)
- Tomography, X-Ray Computed
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