Abstract | BACKGROUND: METHODS AND RESULTS: In 41 patients undergoing elective PTCA, plasma samples were tested for the ACB assay, CK-MB, myoglobin, and cTn-I before, immediately after, and 6 and 24 hours after PTCA. Thirteen additional patients served as a control group with albumin- cobalt assays performed before and after diagnostic coronary catheterization without angioplasty. ACB assay results demonstrated a significant mean percent difference (10.1%) immediately after PTCA compared with baseline (P < .000001) and returned to baseline by 6 hours after PTCA. ACB assay differences immediately after PTCA were significantly greater than in the control group (10.1% vs -0.9%, P < .001). Mean CK-MB, myoglobin, and cTn-I values were not elevated above baseline immediately after PTCA but were significantly elevated above baseline 6 and 24 hours after PTCA. CONCLUSIONS: These preliminary results suggest that human albumin undergoes a significant reduction in its capacity to bind exogenous cobalt soon after transient coronary occlusion during human PTCA and before significant elevations of CK-MB, myoglobin, or cTn-I. Further confirmatory investigations are warranted to determine if the ACB assay is a useful diagnostic test for early myocardial ischemia.
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Authors | D Bar-Or, J V Winkler, K Vanbenthuysen, L Harris, E Lau, F W Hetzel |
Journal | American heart journal
(Am Heart J)
Vol. 141
Issue 6
Pg. 985-91
(Jun 2001)
ISSN: 0002-8703 [Print] United States |
PMID | 11376314
(Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers
- Isoenzymes
- Myoglobin
- Serum Albumin
- Troponin I
- Cobalt
- Creatine Kinase
- Creatine Kinase, MB Form
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Angioplasty, Balloon, Coronary
- Biomarkers
(blood)
- Case-Control Studies
- Cobalt
(metabolism)
- Creatine Kinase
(blood)
- Creatine Kinase, MB Form
- Female
- Humans
- Isoenzymes
(blood)
- Male
- Middle Aged
- Myocardial Ischemia
(diagnosis, therapy)
- Myoglobin
(blood)
- Postoperative Period
- Prospective Studies
- Protein Binding
- Serum Albumin
(metabolism)
- Troponin I
(blood)
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