Long-term effects of pergolide in the treatment of restless legs syndrome.

Abstract

An open follow-up of a controlled study in patients with restless legs syndrome (RLS) shows that the beneficial effect of pergolide on RLS symptoms persists throughout at least 1 year. Twenty-two patients of 28 (78.6%) continued to take pergolide. Polysomnographic measurements showed a persistent improvement of PLM index, PLMS arousal index, total sleep time, and sleep efficiency (p = 0.0001). Side effects, in particular nausea, were common but were well controlled by domperidone in most patients.

• Authors: K Stiasny, T C Wetter, J Winkelmann, U Brandenburg, T Penzel, M Rubin, H P Hundemer, W H Oertel, C Trenkwalder
• Journal: Neurology (Neurology) Vol. 56 Issue 10 Pg. 1399-402 (May 22 2001) ISSN: 0028-3878 [Print] United States
• PMID: 11376198 (Publication Type: Journal Article)

Chemical References

• Dopamine Agonists
• Pergolide

Topics

• Adult
• Aged
• Clinical Trials as Topic
• Dopamine Agonists (administration & dosage, adverse effects)
• Dose-Response Relationship, Drug
• Female
• Follow-Up Studies
• Humans
• Male
• Middle Aged
• Patient Satisfaction
• Pergolide (administration & dosage, adverse effects)
• Polysomnography (drug effects)
• Restless Legs Syndrome (drug therapy, physiopathology)
• Sleep (drug effects, physiology)
• Time Factors
• Treatment Outcome