Treatment of rhinitis medicamentosa with fluticasone propionate--an experimental study.

Abstract

The efficacy of fluticasone propionate aqueous nasal spray (0.05% w/w) in the treatment of rhinitis medicamentosa has been studied in an animal model (guinea pig). Rhinitis medicamentosa was induced through the instillation of 0.05% naphthazoline nitrate (Privine) for 8 weeks. Fluticasone propionate nasal spray was then administered to the animals for 2 weeks. The spray successfully cleared the interstitial edema which is the pathologic hallmark of rhinitis medicamentosa. The study suggests that fluticasone propionate nasal spray can be beneficial in the treatment of patients with rhinitis medicamentosa.

• Authors: S Elwany, S Abdel-Salaam
• Journal: European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery (Eur Arch Otorhinolaryngol) Vol. 258 Issue 3 Pg. 116-9 (Mar 2001) ISSN: 0937-4477 [Print] Germany
• PMID: 11374251 (Publication Type: Journal Article)

Chemical References

• Androstadienes
• Nasal Decongestants
• Fluticasone
• Naphazoline

Topics

• Administration, Intranasal
• Androstadienes (administration & dosage, adverse effects)
• Animals
• Disease Models, Animal
• Drug Hypersensitivity (drug therapy, pathology)
• Fluticasone
• Guinea Pigs
• Microscopy, Electron
• Naphazoline (toxicity)
• Nasal Decongestants (toxicity)
• Nasal Mucosa (drug effects, pathology)
• Rhinitis (chemically induced, drug therapy, pathology)
• Treatment Outcome