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[Malignant solitary fibrous tumor of pleura with focal expression of cytokeratin].

Abstract
Solitary fibrous tumor is a rare circumscribed neoplasm involving usually the pleura and now described in many organs and in the soft tissues with a favorable outcome when completely excised. We report herein a malignant solitary fibrous tumor of the pleura occurring in a 59-year-old woman. The tumor cells strongly expressed vimentin and CD 34. In addition a weak positive staining was obtained using CD 99 and bcl 2. A disconcerting focal immunoreactivity with cytokeratin was observed. Solitary fibrous tumor is composed of loosely arranged spindle cells of variable density and may occasionally mimic malignant mesothelioma, an hemangiopericytoma or synovial sarcoma. Immunohistochemical study is helpful demonstrating a strong positivity for vimentin and CD 34 and absence of staining for epithelial markers and S-100 protein.
AuthorsX Leroy, M C Copin, S Petit, D Moukassa, B Gosselin
JournalAnnales de pathologie (Ann Pathol) Vol. 21 Issue 2 Pg. 153-6 (Apr 2001) ISSN: 0242-6498 [Print] France
Vernacular TitleTumeur fibreuse solitaire pleurale maligne avec expression focale de cytokératine.
PMID11373586 (Publication Type: Case Reports, Journal Article)
Chemical References
  • 12E7 Antigen
  • Antigens, CD
  • Antigens, CD34
  • CD99 protein, human
  • Cell Adhesion Molecules
  • Proto-Oncogene Proteins c-bcl-2
  • Vimentin
  • Keratins
Topics
  • 12E7 Antigen
  • Antigens, CD (analysis)
  • Antigens, CD34 (analysis)
  • Cell Adhesion Molecules (analysis)
  • Female
  • Humans
  • Immunohistochemistry
  • Keratins (analysis)
  • Middle Aged
  • Pleural Neoplasms (chemistry, diagnosis, pathology)
  • Proto-Oncogene Proteins c-bcl-2 (analysis)
  • Vimentin (analysis)

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