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Persistent flank pain, low-grade fever, and malaise in a woman treated with indinavir.

Abstract
This case report describes a 32-year-old woman treated with indinavir who developed mild to moderate flank pain, malaise, and low-grade fever. Sterile pyuria preceded increased serum creatinine levels. Workup revealed persistent pyuria, normal-sized kidneys, a normal intravenous pyelography, and negative urinary cultures. Renal biopsy showed interstitial nephritis and chronic inflammation. Collecting ducts contained crystals. Two months after treatment with indinavir was discontinued, serum creatinine levels returned to normal and pyuria disappeared. Sterile pyuria in patients taking indinavir may help to identify patients at risk for renal dysfunction and interstitial nephritis. Markedly increasing the fluid intake above the recommended dosage may ameliorate or even reverse the process of tubulointerstitial disease.
AuthorsM Sarcletti, R Zangerle
JournalAIDS patient care and STDs (AIDS Patient Care STDS) Vol. 13 Issue 2 Pg. 81-7 (Feb 1999) ISSN: 1087-2914 [Print] United States
PMID11362124 (Publication Type: Case Reports, Journal Article)
Chemical References
  • HIV Protease Inhibitors
  • Indinavir
Topics
  • Adult
  • Female
  • Fever (etiology)
  • HIV Infections (complications, drug therapy)
  • HIV Protease Inhibitors (adverse effects)
  • HIV-1
  • Humans
  • Indinavir (adverse effects)
  • Nephritis, Interstitial (chemically induced, complications, diagnosis)
  • Pain (etiology)
  • Pyuria (complications)

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