Prophylactic and therapeutic effects of a humanized monoclonal antibody against the IL-2 receptor (DACLIZUMAB) on collagen-induced arthritis (CIA) in rhesus monkeys.

Abstract	CIA in the rhesus monkey is an autoimmune-based polyarthritis with inflammation and erosion of synovial joints that shares various features with human rheumatoid arthritis (RA). The close phylogenetic relationship between man and rhesus monkey makes the model very suitable for preclinical safety and efficacy testing of new therapeutics with exclusive reactivity in primates. In this study we have investigated the prophylactic and therapeutic effects of a humanized monoclonal antibody (Daclizumab) against the alpha-chain of the IL-2 receptor (CD25). When Daclizumab treatment was started well after immunization but before the expected onset of CIA a significant reduction of joint-inflammation and joint-erosion was observed. A therapeutic treatment, initiated as soon as the first clinical signs of CIA were observed, proved also effective since joint-degradation was abrogated. The results of this study indicate that Daclizumab has clinical potential for the treatment of RA during periods of active inflammation and suppression of the destruction of the joint tissues.
Authors	H P Brok, J M Tekoppele, J Hakimi, J A Kerwin, E M Nijenhuis, C W De Groot, R E Bontrop, B A 't Hart
Journal	Clinical and experimental immunology (Clin Exp Immunol) Vol. 124 Issue 1 Pg. 134-41 (Apr 2001) ISSN: 0009-9104 [Print] England
PMID	11359452 (Publication Type: Journal Article)
Chemical References	Antibodies, Monoclonal Antibodies, Monoclonal, Humanized Autoantibodies Immunoglobulin G Receptors, Interleukin-2 Collagen C-Reactive Protein Daclizumab Hydroxyproline
Topics	Animals Antibodies, Monoclonal (therapeutic use) Antibodies, Monoclonal, Humanized Antibody Specificity Arthritis, Rheumatoid (chemically induced, drug therapy, pathology, prevention & control) Autoantibodies (blood, immunology) Autoimmune Diseases (chemically induced, drug therapy, pathology, prevention & control) C-Reactive Protein (analysis) Collagen (immunology, toxicity) Daclizumab Disease Models, Animal Drug Evaluation, Preclinical Humans Hydroxyproline (urine) Immunization Immunoglobulin G (therapeutic use) Macaca mulatta Male Receptors, Interleukin-2 (antagonists & inhibitors, immunology) Weight Loss

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