Abstract | BACKGROUND: METHODS: A personal series of 13 patients with a mean age of 52 years operated between 1980 and 1996 was reviewed retrospectively. All patients had fasting hypergastrinaemia and recalcitrant ulcer disease with or without diarrhoea. RESULTS: Computed tomography or selective visceral angiography localised the tumour to the pancreas in 6 of 12 elective patients; the thirteenth presented with a perforated duodenal ulcer. All underwent laparotomy with gastrinoma tissue being completely excised in every case, including the 6 patients with failed pre-operative localisation whose tumours arose from the duodenum (4), pancreas (1) and lymph node (1). Eugastrinaemia was achieved in all but 1 patient and was sustained during a mean follow-up of 5.2 years (SD = 4.2 years). These 12 patients remained clinically free of disease during a mean clinical follow-up of 7.5 years (SD = 5.0 years; range 2-19 years). There were no postoperative deaths, but 3 died from recurrent tumour at 3-7 years. CONCLUSION: Since normalisation of serum gastrin was achieved in 12 of 13 patients, laparotomy may well be worthwhile even if the gastrinoma cannot be localised pre-opera- tively.
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Authors | P A Thodiyil, N S El-Masry, R C Williamson |
Journal | Digestive surgery
(Dig Surg)
Vol. 18
Issue 2
Pg. 118-23
( 2001)
ISSN: 0253-4886 [Print] Switzerland |
PMID | 11351156
(Publication Type: Journal Article)
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Copyright | Copyright 2001 S. Karger AG, Basel |
Chemical References |
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Topics |
- Adult
- Aged
- Angiography, Digital Subtraction
- Fasting
- Female
- Gastrectomy
(adverse effects, methods)
- Gastrins
(blood)
- Gastroscopy
- Humans
- Male
- Middle Aged
- Neoplasm Recurrence, Local
(mortality)
- Pancreatectomy
(adverse effects, methods)
- Pancreaticoduodenectomy
(adverse effects, methods)
- Retrospective Studies
- Tomography, X-Ray Computed
- Treatment Outcome
- Zollinger-Ellison Syndrome
(blood, diagnosis, surgery)
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