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[Efficacy of gemcitabine in the gallbladder cancer. Initial experience in 4 cases].

Abstract
Surgery continues to be the only curative therapy for gallbladder cancer, but useful in very few patients. Mean survival of patients with gallbladder cancer, that are out of the reach of surgery, is 3 months. The few clinical trials of chemotherapy for this disease, report very low success rates. We report four patients with advanced gallbladder cancer, treated with gemcitabine in an intravenous dose of 1000 mg/m2, given in 30 min, once a week during three consecutive weeks, every 28 days. There was a partial response that lasted 40.3 23.2 weeks with a mean survival of 59.75 17 weeks. One patient survives without evidences of disease after 17 months of the diagnosis of an advanced cancer. In all patients, symptoms were alleviated, functional status and quality of life improved. Toxicity was mild and did not require reduction in doses or delay in therapy. Therefore, this medication deserves further investigation for the treatment of gallbladder cancer.
AuthorsJ Gallardo, B Rubio, M Ahumada, C Cortés
JournalRevista medica de Chile (Rev Med Chil) Vol. 128 Issue 9 Pg. 1025-30 (Sep 2000) ISSN: 0034-9887 [Print] Chile
Vernacular TitleEficacia de gemcitabina en cáncer de vesícula biliar. Experiencia inicial en cuatro casos.
PMID11349491 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Antimetabolites, Antineoplastic
  • Deoxycytidine
  • Gemcitabine
Topics
  • Adenocarcinoma (diagnostic imaging, drug therapy)
  • Adult
  • Antimetabolites, Antineoplastic (therapeutic use)
  • Chemotherapy, Adjuvant (methods)
  • Deoxycytidine (analogs & derivatives, therapeutic use)
  • Fatal Outcome
  • Female
  • Gallbladder Neoplasms (diagnostic imaging, drug therapy)
  • Humans
  • Male
  • Middle Aged
  • Tomography, X-Ray Computed
  • Treatment Outcome
  • Gemcitabine

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