Abstract | OBJECTIVE: To review the data surrounding the use of tacrolimus for skin disorders. DATA SOURCES: Articles were obtained through a MEDLINE search of English-language literature (1990-May 2000); references of the retrieved publications were further reviewed for relevant literature. STUDY SELECTION: Orginal studies in humans regarding the use of tacrolimus for skin disorders were included. DATA EXTRACTION: The major outcomes extracted from the literature involved patient response to therapy and adverse effects. DATA SYNTHESIS: CONCLUSIONS: Most of the available data indicate short-term (3 wk to 3 mo) topical tacrolimus is a safe and effective treatment alternative for inflammatory skin disorders. Further study is needed to evaluate long-term safety and efficacy and to determine the best dosage regimen. Although oral tacrolimus has demonstrated efficacy in inflammatory skin disorders, the potenial for serious adverse effects limits its utility to third-line therapy for patients who are resistant to, or intolerant of, conventional therapies.
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Authors | P A Skaehill |
Journal | The Annals of pharmacotherapy
(Ann Pharmacother)
Vol. 35
Issue 5
Pg. 582-8
(May 2001)
ISSN: 1060-0280 [Print] United States |
PMID | 11346066
(Publication Type: Journal Article, Review)
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Chemical References |
- Immunosuppressive Agents
- Tacrolimus
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Topics |
- Administration, Oral
- Administration, Topical
- Adolescent
- Adult
- Child
- Female
- Humans
- Immunosuppressive Agents
(administration & dosage, therapeutic use)
- Male
- Middle Aged
- Randomized Controlled Trials as Topic
- Skin Diseases
(drug therapy, physiopathology)
- Tacrolimus
(administration & dosage, therapeutic use)
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