Abstract | BACKGROUND: METHODS: Using the chronically catheterized rat model, IBU (60 mg/kg body weight per day) was infused via the gastric catheter twice daily. Pancreatic enzyme (PE; 10,000 U lipase/kg body weight per day) and Ursodiol (10 mg/kg body weight per day) in two doses were infused via the duodenal catheter. Rats were assigned to one of six treatment groups and were administered treatment for 20 days: control, IBU, PE, IBU + PE, IBU + Ursodiol, and IBU + PE + Ursodiol. The entire jejunum, ileum, cecum, and colon were available for histologic analysis using previously described techniques. RESULTS: Addition of Ursodiol to high-dose IBU and normal doses of PE showed a significant reduction in the percentage of rats with ulcers (P < 0.05), total number of serositis events (P < 0.01), total number of severe ulcers (P < 0.001), and an absence of ulcers in the large intestine. CONCLUSIONS:
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Authors | J D Lloyd-Still, D W Beno, M R Uhing, V A Jiyamapa-Serna, R E Kimura |
Journal | Journal of pediatric gastroenterology and nutrition
(J Pediatr Gastroenterol Nutr)
Vol. 32
Issue 3
Pg. 270-3
(Mar 2001)
ISSN: 0277-2116 [Print] United States |
PMID | 11345174
(Publication Type: Journal Article)
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Chemical References |
- Anti-Inflammatory Agents, Non-Steroidal
- Cholagogues and Choleretics
- Ursodeoxycholic Acid
- Lipase
- Ibuprofen
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Topics |
- Animals
- Anti-Inflammatory Agents, Non-Steroidal
(administration & dosage, toxicity)
- Catheterization
- Cholagogues and Choleretics
(therapeutic use)
- Cystic Fibrosis
(complications, drug therapy)
- Disease Models, Animal
- Ibuprofen
(administration & dosage, toxicity)
- Intestinal Diseases
(chemically induced, prevention & control)
- Intestines
(drug effects, pathology)
- Lipase
(administration & dosage)
- Male
- Random Allocation
- Rats
- Rats, Sprague-Dawley
- Serositis
(chemically induced, prevention & control)
- Ulcer
(chemically induced, prevention & control)
- Ursodeoxycholic Acid
(therapeutic use)
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