New therapy complementary to transcatheter arterial embolization for hepatocellular carcinoma.

Abstract

A new therapy complementary to transcatheter arterial embolization (TAE) in which anticancer agents are percutaneously injected into the tumor under ultrasound guidance (percutaneous injection chemotherapy combined with TAE; TAE-PICT) has been developed and found to be effective. A total of 68 hepatocellular carcinoma (HCC) nodules in 50 patients were treated with TAE-PICT, and the complications were evaluated. Among those with solitary HCC nodules < or = 5 cm in diameter, 17 were treated with TAE-PICT and 24 with only TAE in a prospective comparative study. No major complications were seen, and the anticancer drugs could still be found in the tumor 3 months after injection. A significantly higher cumulative survival rate (p= 0.03961) and significantly higher cumulative recurrence-free survival rate (p = 0.00647) were achieved in patients treated with TAE-PICT than in those treated with TAE alone.

• Authors: R Yamada, K Nakamura, N Nishida, T Matsuoka, K Yamada, K Tanaka, M Terada, M Sato
• Journal: World journal of surgery (World J Surg) Vol. 25 Issue 3 Pg. 381-5; discussion 385-6 (Mar 2001) ISSN: 0364-2313 [Print] United States
• PMID: 11343199 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents

Topics

• Aged
• Antineoplastic Agents (administration & dosage)
• Carcinoma, Hepatocellular (drug therapy, mortality, therapy)
• Embolization, Therapeutic
• Female
• Humans
• Liver Neoplasms (mortality, therapy)
• Male
• Middle Aged
• Survival Rate