Abstract |
Erysipelothrix rhusiopathiae is well known to cause disease in dolphins. This disease occurs either in an peracute way, leading to mortality even before clinical signs are observed or in a sub-acute way, characterized by rhomboidal skin lesions, that can be treated with penicillin or its derivatives. Commercial swine vaccines, containing inactivated serotype 2 strains, are currently used for vaccination but it is not known whether these vaccines induce protection against E. rhusiopathiae isolates from dolphins. In the present study, it was demonstrated in a mouse model that vaccination with a commercial swine vaccine (Eurovac Ery, Eurovet, Belgium) containing inactivated serotype 2 E. rhusiopathiae strains induced protection against challenge with three E. rhusiopathiae isolates from dolphins. The duration of the protection varied, depending on the challenging isolate, between 8 and >23 weeks. There was however no positive correlation between the amount of antibodies at the moment of challenge and the observed protection. In conclusion, vaccination trials in mice indicate that commercial serotype 2 swine Erysipelothrix vaccines induce protection against erysipelas caused by dolphin pathogenic isolates.
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Authors | G Lacave, E Cox, J Hermans, L Devriese, B M Goddeeris |
Journal | Veterinary microbiology
(Vet Microbiol)
Vol. 80
Issue 3
Pg. 247-53
(Jun 06 2001)
ISSN: 0378-1135 [Print] Netherlands |
PMID | 11337140
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antibodies, Bacterial
- Bacterial Vaccines
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Topics |
- Animals
- Antibodies, Bacterial
(biosynthesis, blood)
- Bacterial Vaccines
(immunology, standards)
- Cross Reactions
(immunology)
- Dolphins
(immunology, microbiology)
- Enzyme-Linked Immunosorbent Assay
- Erysipelothrix
(immunology)
- Erysipelothrix Infections
(immunology, prevention & control)
- Female
- Male
- Mice
- Mice, Inbred BALB C
- Swine
- Swine Erysipelas
(immunology)
- Vaccination
(veterinary)
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