Polymorphisms of tryptophan hydroxylase gene and the symptomatology of schizophrenia: an association study.

Abstract

Serotonergic neurotransmission may be involved in the etiology of schizophrenia. We systematically searched for human tryptophan hydroxylase (TPH) coding polymorphisms, and detected a novel pentanucleotide repeat deletion polymorphism (GTTTT)4/5 in TPH intron 1b. We also confirmed A779C intron 7. Neither polymorphism showed a significant association with schizophrenia (182 patients with schizophrenia, 148 controls). A significant association, however, between A779C genotypes and the total Manchester Scale (MS) scores was found in male patients (P = 0.045). Subsequently, a significant association was also found between A779C genotypes and the MS negative symptoms scores in male patients (P = 0.030). These results suggest that the TPH gene may play a role in the negative symptoms in male patients with schizophrenia.

• Authors: T Shinkai, O Ohmori, T Suzuki, H Kojima, H Hori, T Terao, J Nakamura
• Journal: Psychiatric genetics (Psychiatr Genet) Vol. 10 Issue 4 Pg. 165-71 (Dec 2000) ISSN: 0955-8829 [Print] England
• PMID: 11324941 (Publication Type: Journal Article)

Chemical References

• DNA Primers
• DNA
• Tryptophan Hydroxylase

Topics

• Alleles
• Base Sequence
• DNA (chemistry, genetics)
• DNA Primers
• Female
• Gene Frequency
• Genotype
• Humans
• Introns
• Male
• Middle Aged
• Molecular Sequence Data
• Point Mutation
• Polymorphism, Genetic
• Reference Values
• Repetitive Sequences, Nucleic Acid
• Restriction Mapping
• Schizophrenia (genetics)
• Schizophrenic Psychology
• Sequence Deletion
• Tryptophan Hydroxylase (genetics)