Abstract | AIM: METHODS: RESULTS: Focal cerebral ischemia-reperfusion resulted in abnormal behavior which could be alleviated by Sal B 10 mg.kg-1 i.v., and nimodipine (Nim) 4 mg.kg-1 i.p. At the same time, Sal B 10 mg.kg-1 and Nim 4 mg.kg-1 could inhibit the decrease in SOD, GSH, and ATP levels and the increase in MDA and LA levels caused by ischemia-reperfusion in brain. CONCLUSION: Sal B showed a protective action against the ischemia-reperfusion induced injury in rat brain by reducing lipid peroxides, scavenging free radicals and improving the energy metabolism.
|
Authors | Y H Chen, G H Du, J T Zhang |
Journal | Acta pharmacologica Sinica
(Acta Pharmacol Sin)
Vol. 21
Issue 5
Pg. 463-6
(May 2000)
ISSN: 1671-4083 [Print] United States |
PMID | 11324448
(Publication Type: Journal Article)
|
Chemical References |
- Antioxidants
- Benzofurans
- Neuroprotective Agents
- Lactic Acid
- Malondialdehyde
- Adenosine Triphosphate
- salvianolic acid B
- Superoxide Dismutase
|
Topics |
- Adenosine Triphosphate
(metabolism)
- Animals
- Antioxidants
(pharmacology)
- Benzofurans
(pharmacology)
- Brain
(metabolism)
- Brain Ischemia
(etiology, metabolism)
- Lactic Acid
(metabolism)
- Male
- Malondialdehyde
(metabolism)
- Neuroprotective Agents
(pharmacology)
- Rats
- Rats, Wistar
- Reperfusion Injury
(etiology, metabolism)
- Superoxide Dismutase
(metabolism)
|