Effects of 2-[3-estrone-N-ethyl-piperazine-methyl]tetracycline (XW630) on osteoporosis in ovariectomized rats.

Abstract

AIM:

To study the effects of 2-[3-estrone-N-ethyl-piperazine-methyl]tetracycline (XW630) on experimental osteoporosis in ovariectomized (OVX) rats.

METHODS:

Serum estradiol (E2) content and bone 1-carboxyglutamic acid-containing protein (BGP) content were measured by radioimmunoassay. With undecalcified bone section and tetracycline intraperitoneal labeling, the bone static and dynamic data were studied in right femur samples.

RESULTS:

After treatment with XW630 2.5 mg.kg-1, serum BGP content increased by 75.7% but there was no change in serum E2 content and uterus weight compared with OVX rats. Compared with OVX rats, the static data of trabecular bone volume/total tissue volume, trabecular bone volume/sponge bone volume, and mean trabecular plate density were enhanced after treatment with XW630 for 13 wk. The dynamic data of single-labeled surface, double-labeled surface, trabecular osteoid surface, and bone formation rate in tissue level in XW630 group were increased and osteoid maturation period was shortened.

CONCLUSION:

XW630 enhanced bone activation frequency and increased trabecular connectivity, stability, and strength. XW630 stimulated bone formation and inhibited bone resorption with no effect on reproductive system.

• Authors: L Sun, M C Qiu, L L Weng, H Zheng, J S Liu
• Journal: Acta pharmacologica Sinica (Acta Pharmacol Sin) Vol. 21 Issue 3 Pg. 200-4 (Mar 2000) ISSN: 1671-4083 [Print] United States
• PMID: 11324415 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• 2-(3-estrone-N-ethyl-piperazine-methyl)tetracycline
• Estrogens, Conjugated (USP)
• Piperazines
• Tetracyclines
• Estrone
• Estradiol
• Tetracycline

Topics

• Animals
• Estradiol (blood)
• Estrogens, Conjugated (USP) (pharmacology)
• Estrone (pharmacology)
• Female
• Femur (drug effects)
• Humans
• Osteoporosis, Postmenopausal (metabolism)
• Ovariectomy
• Piperazines (pharmacology)
• Rats
• Rats, Wistar
• Tetracycline (pharmacology)
• Tetracyclines
• Uterus (drug effects)