Abstract |
The possible role of point mutations in the platelet integrin alpha2 beta1 gene in Turkish children with ischemic stroke was evaluated in this study. The case-control study included 44 pediatric patients with cerebral infarct (age range, 10 months to 18 years) and 96 healthy unrelated individuals. Genotyping was performed according to previously described methods. Distribution of the three haplotypes were 36.4%, 45.3%, 10.4% and 31.8%, 50.0%, 13.6% for the controls and the patients, respectively. A new fourth haplotype was found which was 7.8% and 4.5% respectively. Our data indicated that these haplotypes are not risk factors in pediatric stroke group.
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Authors | N Akar, T Duman, E Akar, G Deda, T Sipahi |
Journal | Thrombosis research
(Thromb Res)
Vol. 102
Issue 2
Pg. 121-3
(Apr 15 2001)
ISSN: 0049-3848 [Print] United States |
PMID | 11323022
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Integrins
- Platelet Membrane Glycoproteins
- Receptors, Collagen
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Topics |
- Adolescent
- Alleles
- Case-Control Studies
- Cerebral Infarction
(etiology, genetics)
- Child
- Child, Preschool
- Gene Frequency
- Genetic Testing
- Genotype
- Humans
- Infant
- Integrins
(genetics)
- Platelet Membrane Glycoproteins
(genetics)
- Receptors, Collagen
- Turkey
(epidemiology)
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