Amelioration of experimental autoimmune encephalomyelitis in C57BL/6 mice by an agonist of peroxisome proliferator-activated receptor-gamma.

Abstract	Peroxisome proliferator-activated receptor-gamma (PPAR-gamma), a member of the nuclear hormone receptor superfamily, plays a critical role in adipocyte differentiation and glucose homeostasis. It has been implicated that PPAR-gamma functions as a regulator of cellular proliferation and inflammatory responses. In the present study, we examined whether troglitazone, a selective PPAR-gamma agonists, ameliorated experimental autoimmune encephalomyelitis (EAE) induced by administration of myelin oligodendrocyte glycoprotein (MOG) peptide 35-55 in C57BL/6 mice. We found that troglitazone attenuated the inflammation and decreased the clinical symptoms. It was suggested that the amelioration was attributed to the attenuation of pro-inflammatory cytokine gene expressions.
Authors	M Niino, K Iwabuchi, S Kikuchi, M Ato, T Morohashi, A Ogata, K Tashiro, K Onoé
Journal	Journal of neuroimmunology (J Neuroimmunol) Vol. 116 Issue 1 Pg. 40-8 (May 01 2001) ISSN: 0165-5728 [Print] Netherlands
PMID	11311328 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Chromans Cytokines Inflammation Mediators Mog protein, mouse Myelin Proteins Myelin-Associated Glycoprotein Myelin-Oligodendrocyte Glycoprotein Peptide Fragments RNA, Messenger Receptors, Cytoplasmic and Nuclear Thiazoles Thiazolidinediones Transcription Factors Troglitazone
Topics	Animals Cell Division (drug effects) Chromans (pharmacology) Cytokines (genetics) Encephalomyelitis, Autoimmune, Experimental (immunology, pathology, prevention & control) Female Inflammation Mediators (physiology) Mice Mice, Inbred C57BL Myelin Proteins Myelin-Associated Glycoprotein (immunology) Myelin-Oligodendrocyte Glycoprotein Peptide Fragments (immunology) RNA, Messenger (antagonists & inhibitors) Receptors, Cytoplasmic and Nuclear (agonists) Reference Values T-Lymphocytes (pathology) Thiazoles (pharmacology) Thiazolidinediones Transcription Factors (agonists) Troglitazone

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!