Abstract |
Treatment with 75 microg/kg/d intravenous (i.v.) anti-D was compared with 50 microg/kg/d in a prospective randomized study of 27 RhD-positive, human immunodeficiency virus-negative, adult, acute, non-splenectomized patients with immune thrombocytopenic purpura ( ITP) and platelet counts < or = 30 x 109/l. The higher dose resulted in greater median d 1 (43 x 109/l vs. 7.5 x 109/l; P = 0.012) and d 7 (153 x 109/l vs. 64.5 x 109/l; P = 0.001) platelet increases despite no greater haemoglobin decrease. Children with acute ITP receiving 75 microg/kg/d had overnight platelet increases in seven out of nine cases. The duration of effect at the 75 microg/kg/d dose was 46 d vs. 21 d (P = 0.03). Adverse events were mild to moderate and ameliorated with prednisone and acetaminophen premedication.
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Authors | G C Newman, M V Novoa, E M Fodero, M L Lesser, B M Woloski, J B Bussel |
Journal | British journal of haematology
(Br J Haematol)
Vol. 112
Issue 4
Pg. 1076-8
(Mar 2001)
ISSN: 0007-1048 [Print] England |
PMID | 11298610
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Analgesics, Non-Narcotic
- Anti-Inflammatory Agents
- Rho(D) Immune Globulin
- Acetaminophen
- Prednisone
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Topics |
- Acetaminophen
(therapeutic use)
- Adult
- Analgesics, Non-Narcotic
(therapeutic use)
- Anti-Inflammatory Agents
(therapeutic use)
- Child
- Drug Administration Schedule
- Humans
- Infusions, Intravenous
- Platelet Count
- Prednisone
(therapeutic use)
- Premedication
- Prospective Studies
- Purpura, Thrombocytopenic
(blood, therapy)
- Rho(D) Immune Globulin
(administration & dosage)
- Statistics, Nonparametric
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