Indomethacin therapy in hydramnios.

Abstract

AIM:

The use of indomethacin in treatment of hydramnios was evaluated.

SUBJECTS & METHODS:

Twelve patients with symptomatic hydramnios were treated with indomethacin (2.2- 3.0 mg/kg body weight/day).

RESULTS:

The treatment was started at a gestational age of 31.17-/+7.94 weeks and continued for 3.74-/+2.3 weeks. Eleven patients responded to the therapy both subjectively and objectively and pregnancies were prolonged by 4.6-/+3.1 weeks (range 0.1-10 weeks). Five women had term deliveries. Six patients had a favourable perinatal outcome. Four patients who had a known congenital anomaly in the foetus, delivered stillborn babies or had an early neonatal death. One patient who did not follow up after commencing therapy delivered a full-term stillbirth. One patient delivered within 1 day of starting therapy. Indomethacin therapy caused no maternal complications.

CONCLUSION:

Indomethacin was effective in the management of hydramnios and preventing it's complications.

• Authors: S Abhyankar, V S Salvi
• Journal: Journal of postgraduate medicine (J Postgrad Med) 2000 Jul-Sep Vol. 46 Issue 3 Pg. 176-8 ISSN: 0022-3859 [Print] India
• PMID: 11298464 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Indomethacin

Topics

• Adult
• Anti-Inflammatory Agents, Non-Steroidal (administration & dosage)
• Drug Administration Schedule
• Female
• Follow-Up Studies
• Gestational Age
• Humans
• Indomethacin (administration & dosage)
• Polyhydramnios (diagnostic imaging, drug therapy)
• Pregnancy
• Pregnancy Outcome
• Severity of Illness Index
• Treatment Outcome
• Ultrasonography, Prenatal (methods)