Abstract | BACKGROUND AND AIM OF THE STUDY:
Aprotinin is effective in promoting hemostasis, notably in cardiac surgery with cardiopulmonary bypass. Its efficacy has been shown in coronary bypass graft operations. However, few reports exist of aprotinin use in valve operations, and in those studies only the full dose was used. Thus, our aim was to evaluate the effects of low-dose aprotinin in patients undergoing heart valve reoperation. METHODS: Eighteen patients having reoperative valve surgery received 10(6) KIU aprotinin after induction of anesthesia, and a further 10(6) KIU in the pump prime. A group of 18 similar patients who were operated on but did not receive aprotinin were used as controls. RESULTS: CONCLUSION:
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Authors | C F Kirzner, A R Correia, O M Azevedo Jr, M V Maranhão, J R Gonçalves, M S Kirzner, A P Xavier, J N Figueiroa |
Journal | The Journal of heart valve disease
(J Heart Valve Dis)
Vol. 10
Issue 2
Pg. 222-7
(Mar 2001)
ISSN: 0966-8519 [Print] England |
PMID | 11297210
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
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Topics |
- Adult
- Aprotinin
(administration & dosage)
- Female
- Heart Valve Diseases
(surgery)
- Heart Valves
(drug effects, surgery)
- Hemostatics
(administration & dosage)
- Humans
- Male
- Middle Aged
- Postoperative Hemorrhage
- Reoperation
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