[A case of small cell lung cancer with paraneoplastic cerebellar degeneration and anti-voltage-gated calcium channel antibody].

Abstract

A 55-year-old man presenting with 4 weeks of progressive dysarthria, gait ataxia and vertigo was admitted to our hospital. Chest X-ray films revealed a mass shadow in the right upper lobe of the lung, and transbronchial brushing specimens showed small-cell carcinoma. Extensive examination revealed metastatic lesions in the mediastinal lymph nodes and liver, but brain MRI showed no findings suggestive of metastasis or atrophy. A diagnosis of PCD associated with SCLC was made, and the patient had a high titer of anti-P/Q-type VGCC antibody. He was treated by chemotherapy and radiation therapy, which resulted in a transient improvement in the PCD symptoms.

• Authors: S Shirai, N Sukoh, H Yamamoto, I Suzuki, A Kamimura, K Yoshida, A Suzuki, M Inoue, N Watanabe
• Journal: Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society (Nihon Kokyuki Gakkai Zasshi) Vol. 39 Issue 1 Pg. 40-4 (Jan 2001) ISSN: 1343-3490 [Print] Japan
• PMID: 11296385 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Autoantibodies
• Calcium Channels, N-Type
• voltage-dependent calcium channel (P-Q type)

Topics

• Autoantibodies (analysis)
• Calcium Channels, N-Type (immunology)
• Carcinoma, Small Cell (diagnosis, immunology, therapy)
• Combined Modality Therapy
• Fatal Outcome
• Humans
• Lung Neoplasms (diagnosis, immunology, therapy)
• Male
• Middle Aged
• Paraneoplastic Cerebellar Degeneration (diagnosis, immunology, therapy)