Abstract |
It has been postulated that variation in the distribution of human leukocyte antigen (HLA)-encoded susceptibility alleles for insulin-dependent diabetes mellitus ( IDDM) is the genetic basis for variation in the incidence of the disease between populations. The aim of this study was to characterize HLA-encoded susceptibility to IDDM in Hungary and to identify whether HLA-DRB1/DQ-encoded susceptibility could account for the five times lower incidence of disease in Hungary compared with Finland. The haplotypes DRB1*03-DQA1*05-DQB1*02 (DRB1*03-DQ2) and DRB1*04-DQA1*0301-DQB1*0302 (DRB1*04-DQ8) were significantly associated with disease in both populations. Three genotypes incorporating either or both of these haplotypes accounted for over 70% of the diabetic population in both races. The combined background frequency and the degree of risk as measured by odds ratios of these HLA-DRB1-DQ genotypes were not significantly different in the two countries. Comparison of the DRB1*0401-DQ8 haplotype between the two races suggested a role for HLA-B alleles in susceptibility. These data indicate that the susceptibility associated with high risk DRB1-DQ genotypes alone is insufficient to account for the fivefold variation in incidence of IDDM between Hungary and Finland. Other genetic and/or environmental influences must be involved.
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Authors | R Hermann, C H Mijovic, M Rayner, N Croft, M A Kelly, D Jenkins, G Soltész, A H Barnett |
Journal | Human immunology
(Hum Immunol)
Vol. 62
Issue 4
Pg. 391-8
(Apr 2001)
ISSN: 0198-8859 [Print] United States |
PMID | 11295472
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- HLA-DQ Antigens
- HLA-DQ alpha-Chains
- HLA-DQ beta-Chains
- HLA-DQA1 antigen
- HLA-DQB1 antigen
- HLA-DR Antigens
- HLA-DRB1 Chains
- HLA-DRB1*04:01 antigen
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Topics |
- Alleles
- Child
- Diabetes Mellitus, Type 1
(epidemiology, genetics, immunology)
- Female
- Finland
(epidemiology)
- Gene Frequency
- Genotype
- HLA-DQ Antigens
(classification, genetics)
- HLA-DQ alpha-Chains
- HLA-DQ beta-Chains
- HLA-DR Antigens
(classification, genetics)
- HLA-DRB1 Chains
- Haplotypes
- Humans
- Hungary
(epidemiology)
- Incidence
- Male
- Risk Factors
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