Enhancement of ethonol-induced withdrawal convulsions by blockade of 5-hydroxytryptamine receptors.

Abstract	Male Swiss-Webster mice were made physically dependent on ethanol using the ethanol vapour inhalation technique. Animals pretreated with methysergide, a known 5-hydroxytryptamine receptor blocking agent, had significantly greater alcohol-induced withdrawal convulsions than saline pretreated controls. These findings suggest that the reduction of 5-HT at receptor sites may result in the augmentation of the withdrawal convulsions.
Authors	K Blum, J E Wallace, H A Schwertner, J D Eubanks
Journal	The Journal of pharmacy and pharmacology (J Pharm Pharmacol) Vol. 28 Issue 11 Pg. 832-5 (Nov 1976) ISSN: 0022-3573 [Print] England
PMID	11292 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)
Chemical References	Receptors, Serotonin Serotonin Ethanol Methysergide
Topics	Animals Ethanol Humans Male Methysergide (pharmacology) Mice Receptors, Serotonin (drug effects) Seizures (physiopathology) Serotonin (physiology) Substance Withdrawal Syndrome (physiopathology) Substance-Related Disorders (physiopathology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!