[Successful therapy with tetracycline and nicotinamide in cicatricial pemphigoid].

Abstract

We describe a case of cicatricial pemphigoid in a 92-year-old female with extensive mucocutaneous involvement. She developed extensive hemorrhagic blistering with severely bleeding lesions, that healed with scarring. The conjunctivae showed extensive synechia. The diagnosis was based on clinical and histopathological features as well as immunofluorescence findings and immunoblot analysis. There was no clinical response to topical corticosteroids. The patient was given tetracycline and nicotinamid and showed rapid improvement of the mucocutaneous lesions within a few weeks. The clinical features, differential diagnosis and various treatment modalities of cicatricial pemphigoid are briefly reviewed, whereby the use of tetracycline and nicotinamide is discussed as an alternative effective and safe therapy for this potentially incapacitating condition.

• Authors: O P Kreyden, L Borradori, R M Trüeb, G Burg, F O Nestle
• Journal: Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete (Hautarzt) Vol. 52 Issue 3 Pg. 247-50 (Mar 2001) ISSN: 0017-8470 [Print] Germany
• Vernacular Title: Erfolgreiche Therapie mit Tetracyclin und Nikotinaminsäure beim vernarbenden Pemphigoid.
• PMID: 11284073 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Anti-Bacterial Agents
• Niacinamide
• Tetracycline

Topics

• Aged
• Aged, 80 and over
• Anti-Bacterial Agents (administration & dosage)
• Drug Therapy, Combination
• Ear, External (pathology)
• Female
• Follow-Up Studies
• Humans
• Niacinamide (administration & dosage)
• Pemphigoid, Benign Mucous Membrane (drug therapy, pathology)
• Skin (pathology)
• Tetracycline (administration & dosage)
• Time Factors