Effectiveness of a single dose of acellular pertussis vaccine to prevent pertussis in children primed with pertussis whole cell vaccine.

Abstract

We estimated the protection given by one booster dose of acellular pertussis vaccine (aP) given at 18 months or before school entry to children already primed with whole cell vaccine (wP). Case-control studies were conducted in these two age groups. In children who received or were eligible to receive their 18 months booster, the risk of pertussis was 1.4 and 3.6 times higher for those with 4 and 3 wP, respectively, compared to those with 3 wP + 1 aP. In 5 and 6 yr old children, the risk of pertussis among the subjects with 5 and 4 wP, was 1.4 and 2.1 times higher respectively than in those who received 4 wP + 1 aP. A single dose of aP increased the protection against pertussis and this protection was greater than that obtained with a wP booster.

• Authors: G De Serres, R Shadmani, N Boulianne, B Duval, L Rochette, M Douville Fradet, S A Halperin
• Journal: Vaccine (Vaccine) Vol. 19 Issue 20-22 Pg. 3004-8 (Apr 06 2001) ISSN: 0264-410X [Print] Netherlands
• PMID: 11282212 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Pertussis Vaccine
• Vaccines, Acellular

Topics

• Age Factors
• Case-Control Studies
• Child
• Child, Preschool
• Humans
• Immunization, Secondary
• Infant
• Pertussis Vaccine (immunology)
• Vaccines, Acellular (immunology)
• Whooping Cough (prevention & control)