Abstract |
The authors investigated the relations between outcome and apoptosis, immunohistochemical demonstration of bcl-2 protein, and immunohistochemical staining for p53 protein in patients with gastrointestinal stromal/ smooth muscle tumors (GIST). Patients whose tumors demonstrated cellular apoptosis using the terminal deoxynucleotidyl transferase-mediated 2'-deoxyuridine 5'-triphosphate-biotin nick end labeling (TUNEL) assay had an improved survival over those whose tumors did not improve. In contrast, patients whose tumors demonstrated staining for bcl-2 protein had a decreased survival compared with those whose tumors did not demonstrate bcl-2. There was no relation between p53 immunoreactivity and survival. These results suggest that inhibition of apoptosis may be associated with malignant behavior in patients with gastrointestinal stromal/ smooth muscle tumors.
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Authors | R E Cunningham, S L Abbondanzo, W S Chu, T S Emory, L H Sobin, T J O'Leary |
Journal | Applied immunohistochemistry & molecular morphology : AIMM
(Appl Immunohistochem Mol Morphol)
Vol. 9
Issue 1
Pg. 19-23
(Mar 2001)
ISSN: 1541-2016 [Print] United States |
PMID | 11277409
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Proto-Oncogene Proteins c-bcl-2
- Tumor Suppressor Protein p53
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Topics |
- Apoptosis
- Gastrointestinal Neoplasms
(metabolism, pathology)
- Humans
- Immunohistochemistry
- In Situ Nick-End Labeling
- Leiomyoma
(metabolism, pathology)
- Leiomyosarcoma
(metabolism, pathology)
- Mitotic Index
- Neoplasms, Connective Tissue
(metabolism, pathology)
- Neoplasms, Muscle Tissue
(metabolism, pathology)
- Proto-Oncogene Proteins c-bcl-2
(metabolism)
- Tumor Suppressor Protein p53
(metabolism)
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