Tumor suppression by pyran copolymer: correlation with production of cytotoxic macrophages.

Abstract

Intraperitoneal administration of pyran copolymer (pyran-2-succinic anhydride-4,5-dicarboxytetrahydro-6-methylanhydride polymer) protected C3H/HeN male mice against tumor development after intradermal challenge with cells of the transplantable, methylcholanthrene-induced, syngeneic fibrosarcoma 1038. Peritoneal cells from pyran-treated but not from normal animals suppressed tumor development in local passive-transfer experiments. Adherent peritoneal cells from pyran-treated mice were cytotoxic in vitro to several syngeneic murine tumor cell lines including 1038.

• Authors: R P Harmel Jr, B zbar
• Journal: Journal of the National Cancer Institute (J Natl Cancer Inst) Vol. 54 Issue 4 Pg. 989-92 (Apr 1975) ISSN: 0027-8874 [Print] United States
• PMID: 1127729 (Publication Type: Journal Article)

Chemical References

• Polymers
• Pyran Copolymer
• Methylcholanthrene

Topics

• Animals
• Ascitic Fluid (cytology)
• Cell Line
• Cytotoxicity Tests, Immunologic
• Fibrosarcoma (chemically induced, immunology, prevention & control)
• Immunization, Passive
• Macrophages (immunology)
• Male
• Methylcholanthrene
• Mice
• Mice, Inbred C3H
• Neoplasm Transplantation
• Polymers (therapeutic use)
• Pyran Copolymer (therapeutic use)
• Sarcoma, Experimental (chemically induced, immunology, prevention & control)
• Transplantation, Homologous