A spectrum of dystonias-clinical features and update on management.

Abstract

Dystonia is an interesting disorder characterized by involuntary movement of the body part or parts leading to abnormal deformed postures. The usual signs and symptoms are local pain, spasm and abnormal movements. Sensory trick is an important clinical phenomenon and is characteristic of dystonia. It is usually separated from other movement disorders such as chorea, athetosis, tics and myoclonus clinically. Various non-dystonic conditions simulate dystonia and need to be separated in view of different line of management. Improved understanding in molecular biology has helped in understanding of the disease. Confusing neuropathology and neurochemistry have deterred the finding of an effective drug, however empirical use of few drugs have improved the gloomy situation. Few conditions such as dopa-responsive dystonia have definite treatment. Recently use of botulinum toxin has provided beneficial response in hyper muscular contraction states such as dystonia and spasticity, Surgery and other non-medical therapies are effective in few situations.

• Authors: S K Das, S S Choudhary
• Journal: The Journal of the Association of Physicians of India (J Assoc Physicians India) Vol. 48 Issue 6 Pg. 622-30 (Jun 2000) ISSN: 0004-5772 [Print] India
• PMID: 11273544 (Publication Type: Journal Article, Review)

Topics

• Diagnosis, Differential
• Dystonia (diagnosis, etiology, therapy)
• Humans
• Prognosis
• Treatment Outcome