Abstract | OBJECTIVE: METHODOLOGY: A randomized, double-blind, placebo-controlled, parallel group study was performed in eight medical centres in Korea. Mild-to-moderate asthma patients who had been treated with beta2-agonists and/or inhaled corticosteroids were studied. The patients' symptoms were evaluated by asthma diary and twice-daily peak flow monitoring. RESULTS: Of the 206 patients enrolled, 197 were eligible for analysis. The pranlukast group (n = 98) showed statistically significant improvement in asthma symptoms, including asthma attack rate, daily living score, and morning and evening asthma scores. Pranlukast significantly reduced the consumption of beta2-agonist. Compared with the placebo group, forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV1) were not significantly higher in the pranlukast group. Morning and evening peak expiratory flow (PEF) were significantly increased after pranlukast treatment at weeks 2 and 4 (380.8 +/- 10.1 L/min at baseline, 394.5 +/- 10.1 at week 2, 396.3 +/- 10.4 at week 4). There were no serious adverse reactions. CONCLUSION:
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Authors | S H Yoo, S H Park, J S Song, K H Kang, C S Park, J H Yoo, B W Choi, M H Hahn, Representing Korea Pranlukast Study Group |
Journal | Respirology (Carlton, Vic.)
(Respirology)
Vol. 6
Issue 1
Pg. 15-21
(Mar 2001)
ISSN: 1323-7799 [Print] Australia |
PMID | 11264758
(Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial)
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Chemical References |
- Adrenergic beta-Agonists
- Chromones
- Leukotriene Antagonists
- pranlukast
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Topics |
- Adrenergic beta-Agonists
(therapeutic use)
- Adult
- Aged
- Analysis of Variance
- Asthma
(drug therapy)
- Chromones
(therapeutic use)
- Consumer Product Safety
- Double-Blind Method
- Female
- Forced Expiratory Volume
(drug effects)
- Humans
- Leukotriene Antagonists
(adverse effects, therapeutic use)
- Male
- Middle Aged
- Peak Expiratory Flow Rate
(drug effects)
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