Serum levels of macrophage colony-stimulating factor in trophoblastic disease.

Abstract

OBJECTIVES:

The aims of this study were to measure levels of colony stimulating factor (CSF-1) in patients with trophoblastic disease, to determine whether such measurement may be useful to supplement measurement of the prognostically reliable human chorionic gonadotrophin (hCG), and to assess whether measurement of CSF-1 may be helpful in predicting requirement for chemotherapy in patients with hydatidiform mole.

METHODS:

Serial weekly serum samples were selected for CSF-1 assay from representative diagnostic groups of patients with trophoblastic disease: hydatidiform-mole with spontaneous resolution, low-risk post-hydatidiform-mole trophoblastic tumor, partial hydatidiform mole, high-risk metastatic gestational trophoblastic tumor, primary ovarian choriocarcinoma, and placental site trophoblastic tumor. hCG was measured by an in-house radioimmunoassay that measures all parts of the hCG molecule. CSF-1 was measured by radioimmunoassay with (125)I-labeled recombinant CSF-1. The upper level of normal CSF-1 was taken as 8 ng/ml.

RESULTS:

In this study of 45 patients with trophoblastic disease, some very high levels of CSF-1 were encountered. In a few patients there was dramatic correlation with hCG. Generally, however, CSF-1 and hCG did not correlate. CSF-1 was frequently not elevated when hCG was still significantly elevated and conversely CSF-1 was elevated when hCG was negative.

CONCLUSION:

The measurement of CSF-1 does not appear to be useful in managing trophoblastic disease as it does not correlate with the level of hCG. Occasionally, high levels of CSF-1 were found in patients with trophoblastic disease.

• Authors: E I Kohorn, B M Kacinski, E R Stanley
• Journal: Gynecologic oncology (Gynecol Oncol) Vol. 80 Issue 3 Pg. 383-6 (Mar 2001) ISSN: 0090-8258 [Print] United States
• PMID: 11263936 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
• Copyright: Copyright 2001 Academic Press.

Chemical References

• Chorionic Gonadotropin
• Macrophage Colony-Stimulating Factor

Topics

• Adolescent
• Adult
• Aged
• Chorionic Gonadotropin (blood)
• Female
• Humans
• Hydatidiform Mole (blood, drug therapy)
• Macrophage Colony-Stimulating Factor (blood)
• Male
• Middle Aged
• Predictive Value of Tests
• Pregnancy
• Radioimmunoassay
• Risk Factors
• Trophoblastic Neoplasms (blood)
• Uterine Neoplasms (blood)