Abstract | OBJECTIVE: METHODS: RESULTS: Twenty-two patients were evaluated. Even at the lowest dose level tested ( paclitaxel 135 mg/m(2) followed by ifosfamide 1 g/m(2)/day x 4 days) grade 4 neutropenia was almost universal, despite the routine use of G-CSF. The alternate drug administration sequence resulted in marrow suppression of similar severity. CONCLUSION: The combination of 24-h infusional paclitaxel with ifosfamide delivered over 4 days results in severe neutropenia, despite the administration of G-CSF, and is not recommended for further evaluation. In view of the known activity of the two agents in several malignancies, including cervix cancer, it would be reasonable to investigate the delivery of the agents employing alternative treatment schedules predicted to result in less severe marrow suppression (e.g., 3-h infusional paclitaxel).
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Authors | M Markman, D Spriggs, R A Burger, L F Carson, S S Lentz, H Gallion |
Journal | Gynecologic oncology
(Gynecol Oncol)
Vol. 80
Issue 3
Pg. 359-63
(Mar 2001)
ISSN: 0090-8258 [Print] United States |
PMID | 11263932
(Publication Type: Clinical Trial, Clinical Trial, Phase I, Journal Article, Multicenter Study, Research Support, U.S. Gov't, P.H.S.)
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Copyright | Copyright 2001 Academic Press. |
Chemical References |
- Methylurea Compounds
- Granulocyte Colony-Stimulating Factor
- methoxuron
- Paclitaxel
- Ifosfamide
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Topics |
- Adult
- Aged
- Antineoplastic Combined Chemotherapy Protocols
(administration & dosage, adverse effects)
- Dose-Response Relationship, Drug
- Drug Administration Schedule
- Female
- Genital Neoplasms, Female
(drug therapy)
- Granulocyte Colony-Stimulating Factor
(administration & dosage)
- Humans
- Ifosfamide
(administration & dosage, adverse effects)
- Infusions, Intravenous
- Methylurea Compounds
- Middle Aged
- Neutropenia
(chemically induced)
- Paclitaxel
(administration & dosage, adverse effects)
- Pelvic Neoplasms
(drug therapy)
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