[Study of the role of the feeding factor in the development of induced experimental mammary cancer in rats].

Abstract

It is studied the influence of two types of experimental diets on rats origin mammary tumors. The first diet was enriched by pig's fat and 2nd diet contained soybean protein and induced N-nitrozo-N-methylurea (MNM). The tumors of rat's mamma were induced by intramammary injections of N-nitrozo-N-methylurea in area of the 2nd left mamma in dose 2.5 mg per rat once a week during 5 weeks. The rats of control group were not exposed to any additional influences except for a carcinogenic one. The rats of first and second subgroup were fed with lard (50 mg/kg) and soybean protein (200 mg/kg) during 30 weeks. It was shown that lard evinced cocarcinnogenic action on the origin of mammary tumors to stimulating their growth and development while the soybean protein considerably reduced frequency of mammary tumors and slowed the time of their appearance.

• Authors: A R Chochieva, F K Dzhioev
• Journal: Voprosy pitaniia (Vopr Pitan) Vol. 69 Issue 5 Pg. 31-3 ( 2000) ISSN: 0042-8833 [Print] Russia (Federation)
• Vernacular Title: Izuchenie roli faktora pitaniia v razvitii indutsirovannogo raka molochnoĭ zhelezy v éksperimente u krys.
• PMID: 11247164 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Dietary Fats
• Soybean Proteins
• Methylnitrosourea
• lard

Topics

• Animals
• Cocarcinogenesis
• Dietary Fats (administration & dosage, adverse effects)
• Female
• Mammary Neoplasms, Experimental (chemically induced, diet therapy, pathology)
• Methylnitrosourea
• Rats
• Soybean Proteins (administration & dosage, therapeutic use)
• Time Factors