[Atherogenesis as a reflection of immune inflammation in the vascular wall].

Abstract

Despite numerous basic and applied studies into the pathogenesis and treatment of atherosclerosis, there is no theory which could explain the development of the whole complex of changes united under the term "atherosclerosis". Examining the causes of atherosclerosis disclosed a pathogenetic association of the immunoregulatory signal CD40-CD40L with the occurrence of arterial atherosclerotic lesions. Studies of the immune mechanisms responsible for the pathogenesis of atherosclerosis (autoimmune complexes containing oxidative modification of LDL, T and B lymphocytes, inflammation mediators, hemoadhesive molecules, and immunoregulatory molecules showed the leading role of autoimmune mechanisms in atherosclerosis. The conceptual result of the studies is that the authors have elucidated the leading role of immune inflammation in the appearance and development of arterial atherosclerotic lesions. The development of a new concept of assessing the pathogenesis of atherosclerosis in the context of immune inflammation in the vascular wall opens new vistas for the treatment of this disease.

• Authors: V A Nagornev, O A Iakovleva, S V Mal'tseva
• Journal: Vestnik Rossiiskoi akademii meditsinskikh nauk (Vestn Ross Akad Med Nauk) Issue 10 Pg. 45-50 ( 2000) ISSN: 0869-6047 [Print] Russia (Federation)
• Vernacular Title: Aterogenez kak otrazhenie razvitiia immunnogo vospaleniia v sosudistoĭ stenke.
• PMID: 11247126 (Publication Type: Journal Article, Review)

Chemical References

• CD40 Antigens
• Cholesterol, LDL

Topics

• Arteries (immunology, ultrastructure)
• Arteriosclerosis (immunology, metabolism, pathology)
• Arteritis (immunology, metabolism, pathology)
• B-Lymphocytes (immunology, ultrastructure)
• CD40 Antigens (immunology)
• Cholesterol, LDL (metabolism)
• Humans
• Immunity, Cellular (immunology)
• T-Lymphocytes (immunology, ultrastructure)