HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Role of organochlorine compounds in the etiology of pancreatic cancer: a proposal to develop methodological standards.

Abstract
Studies on the possible role of organochlorine compounds in the etiology of pancreatic and other cancers face a set of methodologic and logistic issues that stem from the lipophilic nature of most organochlorines, and from the fact that tumor-induced lipid mobilization, weight loss, and metabolic changes can be profound before diagnosis. The question thus arises: do the xenobiotic concentrations in blood and adipose tissue result, in part, from such pathophysiologic changes? To assess and control potential selection and information biases, a flexible framework is warranted. It could be based on indicators such as time elapsed between the first symptom of cancer and blood or fat sample extraction; signs, symptoms and clinical status at the time of extraction; cholesterol and triglycerides levels; other laboratory findings; tumor stage at diagnosis; diagnostic procedures; treatment type and timing; clinical complications; and survival. Before adopting qualitative criteria and quantitative standards, their impact upon causal estimators should be assessed empirically.
AuthorsM Porta
JournalEpidemiology (Cambridge, Mass.) (Epidemiology) Vol. 12 Issue 2 Pg. 272-6 (Mar 2001) ISSN: 1044-3983 [Print] United States
PMID11246593 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Hydrocarbons, Chlorinated
  • DDT
  • Polychlorinated Biphenyls
Topics
  • DDT (adverse effects)
  • Epidemiologic Methods
  • Humans
  • Hydrocarbons, Chlorinated (adverse effects, blood)
  • Lipid Metabolism
  • Pancreatic Neoplasms (chemically induced)
  • Polychlorinated Biphenyls (adverse effects)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: