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Isolated diffuse mesangial sclerosis and Wilms tumor suppressor gene.

Abstract
Diffuse mesangial sclerosis is a rare renal disease, occurring either in isolation or as part of Denys-Drash syndrome. Denys-Drash syndrome originates from mutations of the Wilms tumor suppressor gene (WT1 ). We describe the presence of WT1 mutations in 7 Japanese children with isolated diffuse mesangial sclerosis.
AuthorsS Ito, A Takata, H Hataya, M Ikeda, H Kikuchi, J Hata, M Honda
JournalThe Journal of pediatrics (J Pediatr) Vol. 138 Issue 3 Pg. 425-7 (Mar 2001) ISSN: 0022-3476 [Print] United States
PMID11241056 (Publication Type: Journal Article)
Topics
  • Female
  • Genes, Wilms Tumor (genetics)
  • Glomerular Mesangium (pathology)
  • Humans
  • Infant
  • Infant, Newborn
  • Japan
  • Kidney Diseases (genetics, surgery)
  • Kidney Transplantation
  • Male
  • Point Mutation
  • Sclerosis

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