Expression of granulocyte colony-stimulating factor and its receptor in epithelial skin tumors.

Abstract

Granulocyte colony-stimulating factor receptors (G-CSFR) have been observed on the surface of not only hematopoietic cells but also several cancer cells. In the present study, we investigated the expression of G-CSFR or G-CSF in epithelial skin tumors by immunohistochemical staining. The assessments were defined by the percentage of G-CSFR or G-CSF positive cells and expressed as G-CSFR and G-CSF scores. The G-CSFR score in SCC (77.6+/-20.0%) was significantly higher than that in Bowen's disease (BD) (51.0+/-35.6%), actinic keratosis (AK) (49.3+/-34.6%) or normal skin (30.0+/-32.1%) (P=0.0004, P=0.0003, P<0.0001, respectively). The mean G-CSF score in SCC (56.7+/-27.4%) or in BD (44.1+/-31.4%) was higher than that in normal skin (24.9+/-25.8%) (P=0.0075, P<0.001, respectively). G-CSF expression in AK (29.8+/-31.2%) was lower than that in SCC (P=0.0037). There was significant positive correlation between the G-CSFR score and the G-CSF score (gamma=0.274, P=0.0107) in skin tumors. These findings suggested that the assessment of G-CSFR expression might be associated with carcinogenesis of skin tumors.

• Authors: K Hirai, M Kumakiri, S Fujieda, H Sunaga, L M Lao, Y Imamura, K Ueda, M Fukuda
• Journal: Journal of dermatological science (J Dermatol Sci) Vol. 25 Issue 3 Pg. 179-88 (Apr 2001) ISSN: 0923-1811 [Print] Netherlands
• PMID: 11240265 (Publication Type: Journal Article)

Chemical References

• Ki-67 Antigen
• Receptors, Granulocyte Colony-Stimulating Factor
• Granulocyte Colony-Stimulating Factor

Topics

• Aged
• Bowen's Disease (metabolism)
• Carcinoma, Squamous Cell (metabolism)
• Granulocyte Colony-Stimulating Factor (metabolism)
• Humans
• Immunohistochemistry
• Keratosis (metabolism)
• Ki-67 Antigen (metabolism)
• Receptors, Granulocyte Colony-Stimulating Factor (metabolism)
• Skin (metabolism)
• Skin Neoplasms (metabolism)