Chemokine receptor expression on T cells in blood and cerebrospinal fluid at relapse and remission of multiple sclerosis: imbalance of Th1/Th2-associated chemokine signaling.

Abstract

The expression of chemokine receptors on lymphocytes in the blood and CSF of multiple sclerosis (MS) patients was analyzed at relapse and remission. Both CD4+ and CD8+ cells in CSF at relapse were enriched for Th1-type receptors CXCR3 and CCR5 expression, and were reduced for Th2-type receptors CCR3 and CCR4 expression compared with those of the blood. CCR1 and CCR2 expressions on T cells were increased in CSF and blood, respectively. At remission, CCR5 expression, but not CXCR3 expression, was reduced in CSF CD4+ cells. A biased Th1/Th2 balance may play a critical role in active inflammation and CCR5 on CSF CD4+ cells is a good marker of the disease activity.

• Authors: T Misu, H Onodera, K Fujihara, K Matsushima, O Yoshie, N Okita, S Takase, Y Itoyama
• Journal: Journal of neuroimmunology (J Neuroimmunol) Vol. 114 Issue 1-2 Pg. 207-12 (Mar 01 2001) ISSN: 0165-5728 [Print] Netherlands
• PMID: 11240033 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers
• CCR1 protein, human
• CCR2 protein, human
• CCR4 protein, human
• CXCR3 protein, human
• Receptors, CCR1
• Receptors, CCR2
• Receptors, CCR4
• Receptors, CCR5
• Receptors, CXCR3
• Receptors, Chemokine

Topics

• Adult
• Biomarkers
• CD4-Positive T-Lymphocytes (immunology, metabolism)
• CD8-Positive T-Lymphocytes (immunology, metabolism)
• Female
• Humans
• Male
• Multiple Sclerosis, Relapsing-Remitting (blood, cerebrospinal fluid, immunology)
• Receptors, CCR1
• Receptors, CCR2
• Receptors, CCR4
• Receptors, CCR5 (immunology, metabolism)
• Receptors, CXCR3
• Receptors, Chemokine (immunology, metabolism)
• Recurrence
• Remission, Spontaneous
• Signal Transduction (immunology)
• Th1 Cells (immunology, metabolism)
• Th2 Cells (immunology, metabolism)