Abstract | OBJECTIVE: SETTING: A tertiary teaching hospital in a large urban city in South Africa. PARTICIPANTS: DESIGN: A prospective, double-blind randomised placebo-controlled trial. METHODS: RESULTS:
Wound infection was the most common complication occurring in 13.3% and 12.5% of women in the placebo and cefoxitin groups, respectively. Prophylactic antibiotics did not decrease febrile morbidity, wound infection, endometritis, urinary tract infection and pneumonia. Women who received cefoxitin stayed on average a day less in hospital than those who received placebo (6.9 vs 7.8 days, risk difference 0.94 CI 1.57 - 0.31 days). Eleven women (4.6%) in the placebo group and eight (3.4%) in the cefoxitin group had microbiological evidence of wound infection. Staphylococcus aureus was the most common pathogen (43%) isolated. Similar proportions in both groups (6.3% placebo and 5.1% cefoxitin) required a course of therapeutic antibiotics. CONCLUSION:
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Authors | J S Bagratee, J Moodley, I Kleinschmidt, W Zawilski |
Journal | BJOG : an international journal of obstetrics and gynaecology
(BJOG)
Vol. 108
Issue 2
Pg. 143-8
(Feb 2001)
ISSN: 1470-0328 [Print] England |
PMID | 11236113
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
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Topics |
- Adult
- Antibiotic Prophylaxis
(methods)
- Cefoxitin
(therapeutic use)
- Cephamycins
(therapeutic use)
- Cesarean Section
(methods)
- Double-Blind Method
- Female
- Humans
- Length of Stay
- Obstetric Labor Complications
(prevention & control)
- Pregnancy
- Prospective Studies
- Puerperal Infection
(prevention & control)
- Staphylococcal Infections
(prevention & control)
- Surgical Wound Infection
(prevention & control)
- Treatment Outcome
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