Abstract |
A series of semicarbazones and hydrazones were prepared and evaluated for anticonvulsant activity. Some compounds provided significant protection against maximal electroshock (MES) and subcutaneous strychnine induced seizures (ScSty). Compound 2a emerged as the most active compound at a dose of 30 mg/kg in ScSty test. The compounds 1a, 1g and 2a-e showed significant potentiation of sedative and hypnotic activity of pentobarbitone sodium. Thus compound 2a could serve as a prototype for future developments.
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Authors | S N Pandeya, H Manjula, J P Stables |
Journal | Die Pharmazie
(Pharmazie)
Vol. 56
Issue 2
Pg. 121-4
(Feb 2001)
ISSN: 0031-7144 [Print] Germany |
PMID | 11234338
(Publication Type: Journal Article)
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Chemical References |
- Anticonvulsants
- Convulsants
- Hypnotics and Sedatives
- Semicarbazones
- Strychnine
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Topics |
- Animals
- Anticonvulsants
(chemical synthesis, pharmacology)
- Chemical Phenomena
- Chemistry, Physical
- Convulsants
(antagonists & inhibitors, toxicity)
- Drug Design
- Electroshock
- Hypnotics and Sedatives
(chemical synthesis, pharmacology)
- Magnetic Resonance Spectroscopy
- Rats
- Seizures
(chemically induced, prevention & control)
- Semicarbazones
(chemical synthesis, pharmacology)
- Spectrophotometry, Infrared
- Stereoisomerism
- Strychnine
(antagonists & inhibitors, toxicity)
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